Fig. 1 · Structure

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FR186054

Acyl-Coenzyme A:Cholesterol Acyltransferase Inhibitor

FR186054 is a potent inhibitor of acyl-Coenzyme A:cholesterol acyltransferase (ACAT) with an IC50 of 99 nM. This compound demonstrates hypocholesterolemic effects and is valuable for research involving hypercholesterolemia and atherosclerosis. Its ability to modulate cholesterol metabolism makes it a useful tool for exploring lipid-related disorders.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 179053-90-8
Applications Acyl-Coenzyme A:Cholesterol Acyltransferase Inhibitor
Formula C26H27N5OS2
Molecular Weight 489.66
SMILES
O=C(N(CC1=CC=CC(C2=NNC=C2)=C1)CC3=CC=CC=C3)NC4=C(SC)N=C(C)C=C4SC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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