Documents & Downloads
Fresolimumab
Fresolimumab (GC1008) is a human monoclonal antibody designed to target and neutralize all active mammalian subtypes of Transforming Growth Factor-beta (TGF-β). It exhibits a high binding affinity to TGF-β2, with a dissociation constant (Kd) of 1.8 nM, indicating robust interaction with this cytokine. When conjugated with the radiolabel 89Zr, Fresolimumab serves as a valuable tool for Positron Emission Tomography (PET) analysis, facilitating the study of TGF-β expression, antibody biodistribution, and organ-specific uptake. This antibody is extensively applicable in research focused on cancer, fibrosis, osteogenesis imperfecta, and kidney disease, providing insights into the pathophysiological roles of TGF-β in these conditions.
In Stock
Product Details
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 948564-73-6 |
| Molecular Weight | 144400 |
| Synonyms | GC1008 |
Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.