Fig. 1 · Structure
Documents & Downloads
Frovatriptan succinate hydrate
5-HT1B/1D Receptor Agonist
Frovatriptan succinate hydrate is a selective agonist for the 5-HT1B and 5-HT1D receptors, exhibiting a pK50 value of 8.2. It demonstrates over 10-fold selectivity for these serotonin receptors compared to 5-HT1A, 5-HT1F, and 5-HT7, and exhibits greater than 1000-fold selectivity over other serotonin, dopamine, histamine H1, and α1-adrenoceptors. This compound is valuable for research into migraine pathophysiology and therapeutic applications.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 158930-17-7 |
| Applications | 5-HT1B/1D Receptor Agonist |
| Formula | C18H25N3O6 |
| Molecular Weight | 379.41 |
| Synonyms | (R)-Frovatriptan succinate hydrate; SB 209509 succinate hydrate; VML 251 succinate hydrate |
| SMILES | O=C(O)CCC(O)=O.O=C(C1=CC2=C(NC3=C2C[C@H](NC)CC3)C=C1)N.O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.