Fig. 1 · Structure
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Frovatriptan
5-HT Agonist
Frovatriptan is a selective agonist of the 5-HT1B and 5-HT1D serotonin receptors, exhibiting the highest potency for 5-HT1B among the triptan class. It demonstrates cerebroselectivity, making it particularly effective in targeting migraine pathophysiology. Frovatriptan is effective in alleviating migraine attacks, including those occurring during the headache phase with aura, highlighting its relevance in migraine research and therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 158747-02-5 |
| Applications | 5-HT Agonist |
| Formula | C14H17N3O |
| Molecular Weight | 243.30 |
| Synonyms | (R)-Frovatriptan; SB 209509; VML 251 |
| SMILES | O=C(C1=CC2=C(NC3=C2C[C@H](NC)CC3)C=C1)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.