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Fsh receptor-binding inhibitor fragment(bi-10)

Catalog No.: A60667
FSH Antagonist
FSH receptor-binding inhibitor fragment (bi-10) is a specific antagonist of the follicle-stimulating hormone (FSH) receptor (FSHR). This compound effectively inhibits FSH from binding to its receptor, thereby modifying FSH activity at the receptor level. Research indicates that bi-10 can suppress ovulation and induce follicular atresia in murine models. Additionally, it may offer potential therapeutic strategies for mitigating ovarian cancer by downregulating the overexpression of FSHR and estrogen receptor beta (ERβ) in ovarian tissues.
Fsh receptor-binding inhibitor fragment(bi-10) 163973-98-6 FSH Antagonist
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Size Price Stock Qty
5mg
$105.00
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10mg
$175.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionFSH receptor-binding inhibitor fragment (bi-10) is a specific antagonist of the follicle-stimulating hormone (FSH) receptor (FSHR). This compound effectively inhibits FSH from binding to its receptor, thereby modifying FSH activity at the receptor level. Research indicates that bi-10 can suppress ovulation and induce follicular atresia in murine models. Additionally, it may offer potential therapeutic strategies for mitigating ovarian cancer by downregulating the overexpression of FSHR and estrogen receptor beta (ERβ) in ovarian tissues.
Product Information
Catalog NumA60667
FormulaC42H67N13O19
Molecular Weight1058.06
CAS Number163973-98-6
SequenceThr-Glu-Asn-Leu-Glu-Pro-Asn-Gly-Glu-Gly-NH2
Sequence shorteningTENLEPNGEG-NH2
SMILESC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@@H](C)O)N)=O)CCC(O)=O)=O)CC(N)=O)=O)CC(C)C)=O)CCC(O)=O)(=O)N1[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(N)=O)=O)CCC(O)=O)=O)=O)CC(N)=O)=O)CCC1
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Endocrinology-Hormones > GnRH receptor