Fig. 1 · Structure
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FTO-IN-12
FTO Inhibitor
FTO-IN-12 is an inhibitor of fat mass and obesity-related protein (FTO), with a Kd value of 185 nM and an IC50 of 1.46 μM. This compound plays a significant role in the modulation of RNA methylation and has potential implications in the study of neurodegenerative diseases. Its efficacy in target engagement makes it a valuable tool for researchers investigating the molecular mechanisms underlying obesity and related metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 955328-22-0 |
| Applications | FTO Inhibitor |
| Formula | C10H7ClN2O2 |
| Molecular Weight | 222.63 |
| SMILES | O=C(O)C1=C(N)C2=CC=CC(Cl)=C2N=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.