Fig. 1 · Structure
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FTO-IN-8
FTO Inhibitor
FTO-IN-8 is a potent inhibitor of the N6-methyladenosine demethylase FTO (fat mass- and obesity-associated protein), exhibiting an IC50 value of 5.5 μM. This compound demonstrates anti-cancer cell proliferative activity, making it a valuable tool for research into cancer biology and potential therapeutic strategies targeting FTO in various malignancies. Its ability to modulate RNA methylation offers insights into cellular mechanisms related to obesity and related diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2640366-38-5 |
| Applications | FTO Inhibitor |
| Formula | C19H23ClN2O2 |
| Molecular Weight | 346.85 |
| SMILES | ClC1=CC=CC=C1C2=CC=C(CNCC3(N4CCCC4)COC3)O2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.