Fig. 1 · Structure
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Fumagilin-105
AUTOTAC
Fumagilin-105 is an autophagy-targeting chimera (AUTOTAC) that selectively degrades MetAP2 through p62-mediated macroautophagy in a ubiquitination-independent manner. This compound demonstrates significant anti-tumor activity, inhibiting tumor cell migration and inducing programmed cell death. Fumagilin-105 serves as a valuable tool in cancer research, particularly in studies focusing on autophagy and targeted degradation pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2410081-58-0 |
| Applications | AUTOTAC |
| Formula | C46H60N2O9 |
| Molecular Weight | 784.98 |
| SMILES | C[C@]1([C@H](O1)C/C=C(C)\C)[C@]2([H])[C@]3(CC[C@H]([C@H]2OC)OC(/C=C/C=C/C=C/C=C/C(NCCOCCOCCNCC4=CC(OCC5=CC=CC=C5)=CC=C4)=O)=O)CO3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.