Fig. 1 · Structure
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Fumarate hydratase-IN-2 sodium salt
Fumarate Hydratase Inhibitor
Fumarate hydratase-IN-2 sodium salt is a competitive inhibitor of fumarate hydratase, exhibiting a binding affinity (Ki) of 4.5 μM. This compound is cell-permeable and demonstrates nutrient-dependent cytotoxicity, making it a valuable tool for investigating metabolic pathways and cellular responses in cancer research. Its ability to inhibit fumarate hydratase may have implications for therapeutic strategies targeting metabolic dysregulation in tumors.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2070009-45-7 |
| Applications | Fumarate Hydratase Inhibitor |
| Formula | C25H25N2NaO4 |
| Molecular Weight | 440.47 |
| SMILES | O=C(O[Na])[C@]1([C@H](CC(NC)=O)C2=O)C(N2CC(C=C3)=CC=C3C4=CC=CC=C4)=CCCC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.