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FXIIa-IN-5

FXIIa Inhibitor

FXIIa-IN-5 is a selective orally active inhibitor of factor XIIa (FXIIa), exhibiting an IC50 of 21 nM. This compound interferes with the intrinsic coagulation pathways, demonstrating notable anti-inflammatory and antithrombotic activities in Carrageenan-induced thrombosis models in mice. FXIIa-IN-5 possesses moderate pharmacokinetic properties and displays slight toxicity at a dosage of 100 mg/kg, making it a valuable tool for research into coagulation and inflammatory processes.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3047411-80-0
Applications	FXIIa Inhibitor
Formula	C₂₆H₂₉N₇O
Molecular Weight	455.55
SMILES	O=C(C1=C2C(C=CC=C2)=C(C=C1)N3CCN(CCC3)C(C)C)N4N=C(N=C4N)C5=CC=CC=N5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.