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FZD7 antagonist 1

FZD7 Antagonist

FZD7 Antagonist 1 is a selective antagonist targeting the Frizzled 7 (FZD7) receptor, specifically inhibiting the interaction with Wnt3a with an IC50 of 9.2 nM. This compound disrupts the TcdB-FZD interaction, making it a valuable tool for investigating Wnt signaling pathways and their implications in various biological processes, including cancer and developmental biology. Its application in research provides insights into FZD7-related mechanisms and potential therapeutic targets.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	2416664-25-8
Applications	FZD7 Antagonist
Formula	C₁₄₂H₂₀₂N₃₂O₄₂S₄
Molecular Weight	3157.57
SMILES	C([C@@H](C(N[C@H](C(N[C@@H](CC1=CN=CN1)C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(N)=O)=O)CCSC)=O)[C@H](CC)C)=O)=O)CSSC[C@H](NC([C@H](CC=3C=4C(NC3)=CC=CC4)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)[C@@H](C)O)=O)CC(O)=O)=O)CC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)CC(C)C)=O)=O)C(N[C@@H](CC5=CN=CN5)C(N[C@H](C(N[C@H](C(N[C@@H](CC6=CC=C(O)C=C6)C(N)=O)=O)CCSC)=O)[C@H](CC)C)=O)=O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)[C@@H](C)O)=O)CC(O)=O)=O)CC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)CC(C)C)=O)C=7C=8C(NC7)=CC=CC8

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.