Fig. 1 · Structure
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FzM1
FZD4 Inhibitor
FzM1 is a negative allosteric modulator of the Frizzled receptor FZD4. This compound effectively inhibits WNT5A-dependent WNT responsive element (WRE) activity with an IC50 of approximately 6.2. By binding to an allosteric site in the intracellular loop 3 of FZD4, FzM1 induces conformational changes that disrupt the WNT/β-catenin signaling cascade. This enables its use in research applications focusing on modulating WNT pathway activity in various biological systems.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1680196-54-6 |
| Applications | FZD4 Inhibitor |
| Formula | C21H16N2O2S |
| Molecular Weight | 360.43 |
| SMILES | O=C(NC1=CC2=CC=CC=C2C=C1)NC3=CC(O)=CC(C4=CC=CS4)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.