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γ-Kainylglutamic acid

Neuroexcitation Antagonist

γ-Kainylglutamic acid, a dipeptide antagonist of neuroexcitation, selectively inhibits amino acid-induced stimulation. It effectively blocks Na+ fluxes triggered by the neuroexcitant N-methyl-D-aspartic acid in brain slices and demonstrates anticonvulsant activity. Notably, γ-Kainylglutamic acid protects against picrotoxin-induced convulsions in mice, with an EC50 value of 0.17 μmol. This compound is valuable for research in neuroscience and pharmacology, particularly in the study of excitatory neurotransmission and seizure management.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	98394-38-8
Applications	Neuroexcitation Antagonist
Formula	C₁₅H₂₂N₂O₇
Molecular Weight	342.34
Synonyms	γ-Kainic acid-glutamic acid
SMILES	OC(CC[C@@H](C(O)=O)NC(C[C@H]1[C@H](CN[C@@H]1C(O)=O)C(C)=C)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.