G007-LK

Catalog No.: A15528

TNKS inhibitor

G007-LK

G007-LK Chemical Structure

CAS NO. 1380672-07-0

G007-LK displays high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice,

Availability: In stock

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5 mg

Regular Price: $80.00

Special Price $64.00

10 mg

Regular Price: $140.00

Special Price $112.00

25 mg

Regular Price: $300.00

Special Price $240.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Dominic B. Bernkopf, .et al. An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy, Nat Commun, 2019, 10:4251 PMID: 31534175

Biological Activity

G007-LK displays high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice,
Targets
In vitro DMSO 98 mg/mL (184.92 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.87 mL 94.35 mL 188.69 mL
0.5 mM 3.77 mL 18.87 mL 37.74 mL
1 mM 1.89 mL 9.43 mL 18.87 mL
5 mM 0.38 mL 1.89 mL 3.77 mL

*The above data is based on the productmolecular weight 529.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15528
Actions Inhibitor
CAS No. 1380672-07-0
Formula C25H16ClN7O3S
M. Wt 529.96
Purity >98%
Synonyms G007 LK, G007LK
SMILES CS(=O)(=O)C1=CN=C(C=C1)C2=NN=C(N2C3=CC=CC=C3Cl)C=CC4=NN=C(O4)C5=CC=C(C=C5)C#N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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