Fig. 1 · Structure
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G140
cGAS Inhibitor
G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), exhibiting IC50 values of 14.0 nM for human cGAS and 442 nM for mouse cGAS. It demonstrates significant anti-inflammatory activity, making it valuable for research in the fields of immunology and inflammatory diseases. G140 can be utilized to explore the roles of cGAS in cellular signaling and its implications in various pathological conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2369751-07-3 |
| Applications | cGAS Inhibitor |
| Formula | C17H16Cl2N4O2 |
| Molecular Weight | 379.24 |
| SMILES | OCC(N(C1)CCC(N2)=C1C3=C2C(Cl)=C(Cl)C=C3C4=NN(C)C=C4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.