Fig. 1 · Structure
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G150
cGAS Inhibitor
G150 is a highly selective inhibitor of human cyclic GMP-AMP synthase (h-cGAS), exhibiting an IC50 value of 10.2 nM. This compound effectively represses dsDNA-triggered interferon expression, making it a valuable tool for investigating inflammatory responses. G150 can be utilized in research focused on innate immune signaling and the modulation of inflammatory pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2369751-30-2 |
| Applications | cGAS Inhibitor |
| Formula | C18H16Cl2N4O2 |
| Molecular Weight | 391.25 |
| SMILES | NC1=CC=C(C2=C3C(NC4=C3CN(C(CO)=O)CC4)=C(Cl)C(Cl)=C2)C=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.