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G243-1720

Anti-Orthopoxvirus Agent

G243-1720 is a potent anti-Orthopoxvirus agent that targets the OPG57 (F13) protein, inducing its dimerization. This broad-spectrum inhibitor effectively blocks the replication of various poxviruses while exhibiting no effect on non-poxviruses. G243-1720 disrupts the formation of extracellular membrane virus particles, thus preventing viral spread between cells. In murine models, G243-1720 significantly reduces the viral load of monkeypox virus (MPXV) in lung tissue, highlighting its potential for therapeutic application in poxvirus infections.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	932311-85-8
Applications	Anti-Orthopoxvirus Agent
Formula	C₂₁H₂₈ClN₃O₃S
Molecular Weight	437.98
SMILES	CC1=CC=C(C(Cl)=C1)NS(=O)(C2=C(N(C(C)=C2C(N3CCCCCC3)=O)C)C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.