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GA 0113

Angiotensin II AT1-Receptor Antagonist

GA 0113 is a potent orally active antagonist of the angiotensin II AT1 receptor. It effectively inhibits the pressor response induced by angiotensin II with an ID50 of 0.032 mg/kg, while also demonstrating a dose-dependent increase in plasma renin activity for up to 48 hours. GA 0113 is valuable for research in cardiovascular pharmacology and the study of hypertension mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	200639-61-8
Applications	Angiotensin II AT1-Receptor Antagonist
Formula	C₂₇H₂₄F₃N₅O₂S
Molecular Weight	539.57
SMILES	O=S(NC1=C(C2=NC3=C(C=C2)C=C(CN4C5=NC(C)=CC(C)=C5N=C4CC)C=C3)C=CC=C1)(C(F)(F)F)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.