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Gal-ARV-771

SA-β-Gal Activated PROTAC

Gal-ARV-771 is a galactose-modified PROTAC prodrug designed to target SA-β-Gal-expressed cancer senescent cells for activation. Upon activation, Gal-ARV-771 releases ARV-771, which facilitates the selective degradation of the BRD4 protein via the ubiquitin-proteasome pathway in senescent cells. This compound has demonstrated the capability to induce apoptosis in senescent cancer cells, making it a valuable tool for cancer research focused on cellular senescence and therapeutic strategies targeting BRD4.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3055593-64-8
Applications	SA-β-Gal Activated PROTAC
Formula	C₇₁H₈₄ClN₉O₁₉S₂
Molecular Weight	1467.06
SMILES	O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)OC(OCC4=CC=C(O[C@@H]([C@@H]5OC(C)=O)O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@@H]5OC(C)=O)C=C4)=O)C([C@H](C(C)(C)C)NC(COCCCOCCNC(C[C@@H]6N=C(C7=C(N8C(C)=NN=C68)SC(C)=C7C)C9=CC=C(C=C9)Cl)=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.