Fig. 1 · Structure
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Gamcemetinib
MK2 Inhibitor
Gamcemetinib is a potent and irreversible inhibitor targeting mitogen-activated protein kinase-activated protein kinase-2 (MK2). With an IC50 of 156.3 nM in biochemical assays and an EC50 of 89 nM in cellular studies, Gamcemetinib exhibits robust biological activity, making it a valuable tool for investigating MK2 signaling pathways. This compound is suitable for research applications focused on cancer and inflammatory diseases where MK2 plays a critical role.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1887069-10-4 |
| Applications | MK2 Inhibitor |
| Formula | C22H20ClN5O3S |
| Molecular Weight | 469.94 |
| Synonyms | CC-99677 |
| SMILES | O=C1C2=C(NC[C@H](N1)C)C3=C(S2)C=CC4=NC(OC5=NC(Cl)=NC=C5COCC)=CC=C34 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.