Ganetespib (STA-9090)

Catalog No.: A11402

Hsp90 inhibitor

Ganetespib (STA-9090)

Ganetespib (STA-9090) Chemical Structure

CAS NO. 888216-25-9

Ganetespib is a potent, synthetic, small molecule inhibitor of Hsp90, a chaperone protein that is essential to the function of certain other proteins that drive the growth, proliferation, and survival of many different types of cancer.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$100.00
50 mg
$170.00
100 mg
$260.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Aykut Ozgur, .et al. Investigation of anticancer activities of STA-9090 (ganetespib) as a second generation HSP90 inhibitor in Saos-2 osteosarcoma cells, J Chemother, 2021, Apr 2;1-10 PMID: 33794753
  • Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
  • Kosinsky RL, .et al. USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer, Cell Death Dis, 2019, Dec 4;10(12):911 PMID: 31801945
  • Yamada-Kanazawa S, .et al. Inhibition of heat shock protein 90 exerts an antitumour effect in angiosarcoma: involvement of the vascular endothelial growth factor signalling pathway, Br J Dermatol, 2017, Aug;177(2):456-469 PMID: 28078663
  • Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113

Biological Activity

Ganetespib is a potent, synthetic, small molecule inhibitor of Hsp90, a chaperone protein that is essential to the function of certain other proteins that drive the growth, proliferation, and survival of many different types of cancer.
Targets
HSP90 (OSA 8 cells)
4 nM
In vitro (25°C) DMSO 37 mg/mL (101.53 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+45% PEG 300+ddH2O 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.44 mL 137.21 mL 274.42 mL
0.5 mM 5.49 mL 27.44 mL 54.88 mL
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL

*The above data is based on the productmolecular weight 364.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11402
Actions Inhibitor
CAS No. 888216-25-9
Formula C20H20N4O3
M. Wt 364.4
Purity >98%
Synonyms STA9090
SMILES CC(C)C1=CC(=C2NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)C(=O)C=C1O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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