Fig. 1 · Structure
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Ganfeborole
Leucyl-tRNA Synthetase Inhibitor
Ganfeborole is a potent, selective inhibitor of leucyl-tRNA synthetase in Mycobacterium tuberculosis, exhibiting an IC50 of 0.20 μM. This compound is primarily utilized in research focused on tuberculosis, providing insights into the mechanisms of bacterial protein synthesis inhibition. As an orally active agent, Ganfeborole holds potential for investigating therapeutic strategies against tuberculosis and contributes to the understanding of antibiotic resistance.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2131798-12-2 |
| Applications | Leucyl-tRNA Synthetase Inhibitor |
| Formula | C10H13BClNO4 |
| Molecular Weight | 257.48 |
| Synonyms | GSK656 free base; GSK3036656 free base; GSK070 free base |
| SMILES | OB1O[C@H](CN)C2=C(Cl)C=CC(OCCO)=C21 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.