Ganitumab (AMG 479) is a recombinant human monoclonal antibody specifically targeting the human type 1 insulin-like growth factor receptor (IGF1R). This antibody exhibits high specificity and affinity for murine IGF1R, with a dissociation constant (K_D) of 0.22 nM, effectively inhibiting the interaction between murine IGF1R and its ligands, IGF1 and IGF2. Ganitumab is primarily utilized in oncological research to study the role of the IGF1R pathway in cancer progression and potential therapeutic interventions.
Ganitumab (AMG 479) is a recombinant human monoclonal antibody specifically targeting the human type 1 insulin-like growth factor receptor (IGF1R). This antibody exhibits high specificity and affinity for murine IGF1R, with a dissociation constant (K_D) of 0.22 nM, effectively inhibiting the interaction between murine IGF1R and its ligands, IGF1 and IGF2. Ganitumab is primarily utilized in oncological research to study the role of the IGF1R pathway in cancer progression and potential therapeutic interventions.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
Frequently Asked Questions
What are Biosimilar Antibodies?
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research.
Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
