Fig. 1 · Structure
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GAPDH-IN-1
GAPDH Inhibitor
GAPDH-IN-1 is a potent GAPDH inhibitor with an IC50 value of 39.31 μM for GAPDH enzymatic activity. This compound operates by forming a covalent adduct with aspartic acid at the enzyme's active site, effectively displacing NAD+, a critical cofactor. This mechanism enhances the interaction of cysteine-reactive probes with the catalytic cysteine, making GAPDH-IN-1 valuable for research applications in metabolic studies and enzyme regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 252212-58-1 |
| Applications | GAPDH Inhibitor |
| Formula | C20H18N2O5 |
| Molecular Weight | 366.37 |
| SMILES | C1(C2=CC(OCC3OC3)=CC=C2)=NN=C(C4=CC(OCC5OC5)=CC=C4)O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.