Fig. 1 · Structure
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GBR 12935 fumarate
Dopamine Transporter Inhibitor
GBR 12935 fumarate is a selective inhibitor of the dopamine transporter, characterized by a binding constant (Kd) of 1.08 nM in COS-7 cells. This compound enhances locomotor activity across various mouse strains without inducing stereotypical behavior. Additionally, GBR 12935 fumarate effectively inhibits the head-twitch response induced by d-Fenfluramine in mice, making it valuable for research on dopamine dysregulation-associated disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1349767-56-1 |
| Applications | Dopamine Transporter Inhibitor |
| Formula | C32H38N2O5 |
| Molecular Weight | 530.65 |
| SMILES | O=C(O)/C=C\C(O)=O.N1(CCOC(C2=CC=CC=C2)C3=CC=CC=C3)CCN(CCCC4=CC=CC=C4)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.