Fig. 1 · Structure
Documents & Downloads
GDC-0134
DLK Modulator
GDC-0134 is a selective modulator of dual leucine zipper kinase (DLK) that effectively crosses the blood-brain barrier. By inhibiting DLK's kinase activity, GDC-0134 disrupts the activation of the downstream JNK signaling pathway, thereby preventing DLK-dependent retrograde signal transduction associated with axon-to-soma degeneration and providing neuroprotective effects. This compound has shown promise in reducing TDP-43 protein aggregation and mitigating neuromuscular junction denervation in motor neurons, making it a valuable tool for investigating amyotrophic lateral sclerosis (ALS), Alzheimer's disease, and other neurodegenerative disorders linked to DLK activity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1637394-01-4 |
| Applications | DLK Modulator |
| Formula | C19H20F4N6O2 |
| Molecular Weight | 440.39 |
| SMILES | NC1=C(C=C(C=N1)C2=NC(N3CC(F)(CC3)F)=NC(N4C[C@H]5OC[C@@H]4C5)=C2)OC(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.