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Gem-C12

Gemcitabine Prodrug

Gem-C12 is a prodrug of Gemcitabine, designed to inhibit nucleic acid synthesis by terminating DNA chain elongation, subsequently inducing apoptosis. This compound effectively suppresses the proliferation of glioma cells, making it a valuable tool in glioblastoma multiforme research. Additionally, Gem-C12 demonstrates synergistic anti-glioblastoma activity when used in combination with Honokiol, enhancing its therapeutic potential in targeted cancer treatments.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	849139-19-1
Applications	Gemcitabine Prodrug
Formula	C₂₁H₃₃F₂N₃O₅
Molecular Weight	445.50
SMILES	O=C1N=C(NC(CCCCCCCCCCC)=O)C=CN1[C@H]2C(F)(F)[C@H](O)[C@@H](CO)O2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.