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GEM–IB

Gemcitabine-Ibandronate Conjugate

GEM–IB is a conjugate of gemcitabine (GEM)-5'-phosphate and ibandronate (IB), designed to target osteosarcoma (OS) treatment. This compound exhibits significant reduction in tumor burden, preservation of bone architecture, and enhanced survival in murine models. GEM–IB may offer valuable insights for research into combination therapies and targeted treatments for osteosarcoma.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2866211-93-8
Applications	Gemcitabine-Ibandronate Conjugate
Formula	C₁₈H₃₃F₂N₄O₁₃P₃
Molecular Weight	644.39
SMILES	CCCCCN(CCC(P(O)(O)=O)(P(O)(OP(O)(OC[C@H]1O[C@H](C(F)([C@@H]1O)F)N2C=CC(N)=NC2=O)=O)=O)O)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.