Fig. 1 · Structure
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Gemcitabine triphosphate
Active Metabolite of Gemcitabine
Gemcitabine triphosphate (dFdCTP) is the active metabolite of Gemcitabine, primarily targeting DNA replication pathways. It competes with cytidine triphosphate, effectively inhibiting chain elongation during DNA synthesis. With a Ki value of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε, Gemcitabine triphosphate disrupts both DNA and RNA synthesis, induces cell cycle arrest in G0/G1 and S phases, and promotes apoptosis. This compound is valuable for research applications in pancreatic cancer and non-small cell lung cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 110988-86-8 |
| Applications | Active Metabolite of Gemcitabine |
| Formula | C9H14F2N3O13P3 |
| Molecular Weight | 503.14 |
| Synonyms | dFdCTP |
| SMILES | NC(C=CN1[C@H]2C(F)(F)[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O2)=NC1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.