Gemcitabine triphosphate (dFdCTP) is the active metabolite of Gemcitabine, primarily targeting DNA replication pathways. It competes with cytidine triphosphate, effectively inhibiting chain elongation during DNA synthesis. With a Ki value of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε, Gemcitabine triphosphate disrupts both DNA and RNA synthesis, induces cell cycle arrest in G0/G1 and S phases, and promotes apoptosis. This compound is valuable for research applications in pancreatic cancer and non-small cell lung cancer.
Gemcitabine triphosphate (dFdCTP) is the active metabolite of Gemcitabine, primarily targeting DNA replication pathways. It competes with cytidine triphosphate, effectively inhibiting chain elongation during DNA synthesis. With a Ki value of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε, Gemcitabine triphosphate disrupts both DNA and RNA synthesis, induces cell cycle arrest in G0/G1 and S phases, and promotes apoptosis. This compound is valuable for research applications in pancreatic cancer and non-small cell lung cancer.
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