GFOGER peptide is a collagen-mimetic sequence that functions primarily as a ligand for integrins α2β1, α11β1, and α1β1, promoting integrin-mediated cell adhesion to collagen. This peptide triggers signaling pathways through the α2β1 integrin receptor, facilitating osteoblast differentiation and enhancing bone formation, particularly in challenging femoral defects. GFOGER peptide is suitable for incorporation into biomaterials such as hydrogels and 3D bioinks, making it a valuable tool for tissue engineering applications focused on bone regeneration. Additionally, it can be passively adsorbed onto polymer scaffolds for effective cell-free and growth factor-free bone formation strategies.
GFOGER peptide is a collagen-mimetic sequence that functions primarily as a ligand for integrins α2β1, α11β1, and α1β1, promoting integrin-mediated cell adhesion to collagen. This peptide triggers signaling pathways through the α2β1 integrin receptor, facilitating osteoblast differentiation and enhancing bone formation, particularly in challenging femoral defects. GFOGER peptide is suitable for incorporation into biomaterials such as hydrogels and 3D bioinks, making it a valuable tool for tissue engineering applications focused on bone regeneration. Additionally, it can be passively adsorbed onto polymer scaffolds for effective cell-free and growth factor-free bone formation strategies.
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