Fig. 1 · Structure
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Gigantol
bibenzyl compound
Gigantol is an orally active bibenzyl compound that targets MYC to facilitate its ubiquitin-proteasomal degradation, thereby inhibiting lung cancer cell proliferation. This compound induces ferroptosis through the SLC7A11-GPX4 axis, contributing to its anti-cancer efficacy. Additionally, Gigantol enhances the sensitivity of multidrug-resistant Gram-negative bacteria to colistin and mitigates liver injury caused by carbon tetrachloride by suppressing the JNK/cPLA2/12-LOX inflammatory pathway. Furthermore, it plays a role in cholesterol metabolism and progesterone biosynthesis in Leydig cells, making it valuable for research in lung cancer, antibiotic resistance, and liver inflammation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 83088-28-2 |
| Applications | bibenzyl compound |
| Formula | C16H18O4 |
| Molecular Weight | 274.31 |
| SMILES | OC1=CC(CCC2=CC=C(C(OC)=C2)O)=CC(OC)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.