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Girolline

Protein Synthesis Inhibitor

Girolline is a selective inhibitor of protein synthesis that functions as a modulator of eIF5A. By disrupting the interaction between eIF5A and ribosomes, Girolline induces ribosome stalling, leading to the inhibition of IL-6 and IL-8 production. This compound promotes cell cycle arrest in tumor cells, making it a valuable tool for research in inflammatory diseases, solid tumors, leukemia, and malaria.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	110883-46-0
Applications	Protein Synthesis Inhibitor
Formula	C₆H₁₁ClN₄O
Molecular Weight	190.63
Synonyms	RP 49532
SMILES	NC[C@H](Cl)[C@H](C1=CN=C(N)N1)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.