Documents & Downloads

GIT1-IN-1

GIT1 Inhibitor

GIT1-IN-1 is a selective inhibitor of ARF GTPase-activating protein 1 (GIT1), with a KD of 6.2 μM. This compound demonstrates significant biological activity by inducing apoptosis in liver and colon cancer cells, while also arresting the cell cycle at the G2/M phase and inhibiting cell proliferation, colony formation, and migration. Additionally, GIT1-IN-1 inhibits MEK and ERK activities, decreases cyclin D1 expression, and stabilizes cyclin B1 protein levels, making it a valuable tool for research applications in liver and colon cancer.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	844464-54-6
Applications	GIT1 Inhibitor
Formula	C₂₁H₂₀N₄O₄S
Molecular Weight	424.47
SMILES	O=C(CN1C(C(SC2=C3C=C4C(CC(C)(C)OC4)=N2)=C3N=C1)=O)NCC5=CC=CO5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.