Fig. 1 · Structure
Documents & Downloads
Givosiran
ALAS1 Inhibitor
Givosiran is a small interfering RNA that specifically inhibits hepatic aminolevulinate synthase 1 (ALAS1) by targeting its messenger RNA. This inhibition leads to decreased levels of the neurotoxic compounds δ-aminolevulinic acid (ALA) and porphobilinogen (PBG). Givosiran exhibits significant efficacy in reducing ALAS1 activity in various preclinical models, including mouse, rat, and cynomolgus monkey studies. This reagent is valuable for research focused on acute hepatic porphyria (AHP) and its associated metabolic disturbances.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1639325-43-1 |
| Applications | ALAS1 Inhibitor |
| Molecular Weight | 16300.60 |
| Synonyms | ALN-AS1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.