Fig. 1 · Structure
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GJG057
LTC4S Inhibitor
GJG057 is a selective orally active inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 44 nM. This compound demonstrates significant anti-inflammatory activity in both mouse skin inflammation and asthma models. GJG057 is valuable for research applications focused on inflammation and respiratory diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2761767-18-2 |
| Applications | LTC4S Inhibitor |
| Formula | C21H21F5N4O2 |
| Molecular Weight | 456.41 |
| SMILES | O=C1CCCC2(N1C3=CC=C(C(F)=C3)F)CCN(C4=NC=NC(OCC(F)(F)F)=C4)CC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.