Fig. 1 · Structure
Documents & Downloads
GL64
ADGRD1 Agonist
GL64 is a selective agonist of ADGRD1, exhibiting an EC50 of 3.98 μM. It has some low selectivity towards isoforms such as ADGRD2 and various CELSR and ADGRG proteins. By mimicking the satchel sequence, GL64 activates ADGRD1, leading to the regulation of osteoclast maturation through the cAMP-PKA-NFATC1 signaling pathway. This compound demonstrates the ability to inhibit osteoclastogenesis and prevent bone loss, making it valuable for researching osteoclast-related diseases.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 488801-10-1 |
| Applications | ADGRD1 Agonist |
| Formula | C27H19Cl3N2O2 |
| Molecular Weight | 509.81 |
| SMILES | O=C1C2=CC=CC=C2NC(N1C3=CC=C(C=C3)Cl)C4=CC(OCC5=C(C=C(C=C5)Cl)Cl)=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.