Glabrescione B is a Gli1-DNA interaction inhibitor that targets the Hedgehog (Hh) signaling pathway. This compound disrupts the activity of Gli1 by preventing its binding to DNA, thereby inhibiting the growth of Hedgehog-dependent tumor cells. Additionally, Glabrescione B impairs the self-renewal capacity and clonogenic potential of tumor-derived stem cells, making it a valuable tool for studying Hh-related cancers and stem cell biology.
Glabrescione B is a Gli1-DNA interaction inhibitor that targets the Hedgehog (Hh) signaling pathway. This compound disrupts the activity of Gli1 by preventing its binding to DNA, thereby inhibiting the growth of Hedgehog-dependent tumor cells. Additionally, Glabrescione B impairs the self-renewal capacity and clonogenic potential of tumor-derived stem cells, making it a valuable tool for studying Hh-related cancers and stem cell biology.
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