Fig. 1 · Structure
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Glemanserin
5-HT2A Antagonist
Glemanserin is a potent and selective antagonist for the serotonin receptor 5-HT2A, exhibiting nanomolar affinity in various species (Ki values of 2.89, 0.54, and 2.5 nM for rat, rabbit, and human 5-HT2A, respectively). This compound is primarily utilized in neuropharmacological research to study the role of 5-HT2A receptors in various physiological and pathological conditions. Its antagonistic activity contributes to investigations into mood disorders, anxiety, and other CNS-related ailments.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 107703-78-6 |
| Applications | 5-HT2A Antagonist |
| Formula | C20H25NO |
| Molecular Weight | 295.42 |
| Synonyms | MDL11939 |
| SMILES | OC(C1=CC=CC=C1)C2CCN(CCC3=CC=CC=C3)CC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.