Fig. 1 · Structure
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Glesatinib
MET/SMO Inhibitor
Glesatinib is a potent dual inhibitor of MET and SMO, acting as an oral tyrosine kinase inhibitor. It effectively antagonizes P-glycoprotein-mediated multidrug resistance in non-small cell lung cancer (NSCLC). Its ability to target these key pathways makes Glesatinib a valuable reagent for research focused on cancer treatment and resistance mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 936694-12-1 |
| Applications | MET/SMO Inhibitor |
| Formula | C31H27F2N5O3S2 |
| Molecular Weight | 619.70 |
| Synonyms | MGCD265 |
| SMILES | O=C(NC(NC1=CC=C(OC2=C3C(C=C(C4=NC=C(CNCCOC)C=C4)S3)=NC=C2)C(F)=C1)=S)CC5=CC=C(F)C=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.