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Glucagon receptor antagonist-8

GCGR Antagonist

Glucagon receptor antagonist-8 is a selective antagonist of the human glucagon receptor (GCGR) and p38 mitogen-activated protein (MAP) kinase. It exhibits IC50 values of 0.27 μM for GCGR and 0.16 μM for p38 MAP kinase, demonstrating significant inhibitory activity. This compound is applicable in research focused on metabolic disorders, glucose homeostasis, and signaling pathways associated with glucagon activity.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	208182-31-4
Applications	GCGR Antagonist
Formula	C₂₀H₁₃BrFN₃
Molecular Weight	394.24
SMILES	FC1=CC=C(C2=C(C3=CC=NC=C3)N=C(C4=CC=C(Br)C=C4)N2)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.