Fig. 1 · Structure
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GLUT inhibitor-1
GLUT1/GLUT3 Inhibitor
GLUT inhibitor-1 is a highly potent, orally active inhibitor of glucose transporters, specifically targeting GLUT1 and GLUT3 with IC50 values of 242 nM and 179 nM, respectively. This compound is crucial for research applications focused on cancer metabolism and the modulation of immune responses in autoimmune diseases. Its ability to effectively inhibit glucose uptake makes it a valuable tool in evaluating therapeutic strategies in metabolic and inflammatory conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2421141-40-2 |
| Applications | GLUT1/GLUT3 Inhibitor |
| Formula | C32H35N7O2 |
| Molecular Weight | 549.67 |
| SMILES | O=C(COC1=CC=CC(C2=NC(CCN(C3CCC3)C4)=C4C(NC5=CC=C(C6=CNN=C6)C=C5)=N2)=C1)NC7(CC7)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.