GMQ

Catalog No.: A66941
GABAAR Antagonist
GMQ is a competitive antagonist of the GABAergic receptor, primarily targeting the GABA(A) receptor subtypes α1β2, α1β2γ2, α4β2γ2, and α5β2γ2. This compound potently inhibits GABAAR activity, enhancing neuronal excitation by disrupting GABAergic transmission. Additionally, GMQ offers anti-histaminic effects within the enteric system, specifically inhibiting gastric acid secretion, making it valuable for research in neuropharmacology and gastrointestinal function.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionGMQ is a competitive antagonist of the GABAergic receptor, primarily targeting the GABA(A) receptor subtypes α1β2, α1β2γ2, α4β2γ2, and α5β2γ2. This compound potently inhibits GABAAR activity, enhancing neuronal excitation by disrupting GABAergic transmission. Additionally, GMQ offers anti-histaminic effects within the enteric system, specifically inhibiting gastric acid secretion, making it valuable for research in neuropharmacology and gastrointestinal function.
Product Information
Catalog NumA66941
FormulaC10H11N5
Molecular Weight201.23
CAS Number716-11-0
SMILESNC(NC1=NC(C)=C2C=CC=CC2=N1)=N
Synonyms2-Guanidine-4-methylquinazoline
Useful Calculator

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