GNE-375 is a highly selective inhibitor of BRD9, exhibiting an IC50 of 5 nM. It demonstrates more than 100-fold selectivity for BRD9 compared to BRD4, TAF1, and CECR2. GNE-375 effectively reduces the binding of BRD9 to chromatin, making it a valuable tool for studies of chromatin regulation and the role of BRD9 in epigenetic modulation. This compound is ideal for research applications involving cancer biology and cellular differentiation pathways.
GNE-375 is a highly selective inhibitor of BRD9, exhibiting an IC50 of 5 nM. It demonstrates more than 100-fold selectivity for BRD9 compared to BRD4, TAF1, and CECR2. GNE-375 effectively reduces the binding of BRD9 to chromatin, making it a valuable tool for studies of chromatin regulation and the role of BRD9 in epigenetic modulation. This compound is ideal for research applications involving cancer biology and cellular differentiation pathways.
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