GNE 477

Catalog No.: A14114

PI3K/mTOR inhibitor

GNE 477

GNE 477 Chemical Structure

CAS NO. 1032754-81-6

GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR.

Availability: In stock

Package Price Qty
2 mg
$90.00
5 mg
$170.00
10 mg
$290.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR.
In vitro DMSO 24 mg/mL (47.56 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.82 mL 99.08 mL 198.16 mL
0.5 mM 3.96 mL 19.82 mL 39.63 mL
1 mM 1.98 mL 9.91 mL 19.82 mL
5 mM 0.4 mL 1.98 mL 3.96 mL

*The above data is based on the productmolecular weight 504.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14114
Actions Inhibitor
CAS No. 1032754-81-6
Formula C21H28N8O3S2
M. Wt 504.64
Purity >98%
Synonyms GNE-477,GNE477
SMILES CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)S(=O)(=O)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy GNE 477 | GNE 477 Supplier | purchase | cost | manufacturer | order | distributor | buy 1032754-81-6| 1032754-81-6 Supplier | purchase 1032754-81-6 | 1032754-81-6 cost | 1032754-81-6 manufacturer | order 1032754-81-6 | 1032754-81-6 distributor
Rewards