GNE 477

Catalog No.: A14114

PI3K/mTOR inhibitor

GNE 477

GNE 477 Chemical Structure

CAS NO. 1032754-81-6

GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR.

Availability: In stock

Package Price Qty
2 mg
$90.00
5 mg
$170.00
10 mg
$290.00
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Biological Activity

GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.82 mL 99.08 mL 198.16 mL
0.5 mM 3.96 mL 19.82 mL 39.63 mL
1 mM 1.98 mL 9.91 mL 19.82 mL
5 mM 0.4 mL 1.98 mL 3.96 mL

*The above data is based on the productmolecular weight 504.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14114
Actions Inhibitor
M. Wt 504.64
Formula C21H28N8O3S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1032754-81-6
Synonyms GNE-477,GNE477
SMILES CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)S(=O)(=O)C

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