Fig. 1 · Structure
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GNE 6901
GluN2A PAM
GNE 6901 is a potent positive allosteric modulator (PAM) of the GluN2A subunit of the NMDA receptor (NMDAR), exhibiting an EC50 value of 382 nM. This compound enhances NMDAR activity and is valuable for research into neurological disorders, synaptic plasticity, and cognitive function. GNE 6901 can be utilized in studies aimed at understanding the role of GluN2A in synaptic transmission and the potential therapeutic effects in various neurodegenerative conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1698900-69-4 |
| Applications | GluN2A PAM |
| Formula | C18H17FN2O3S |
| Molecular Weight | 360.40 |
| SMILES | CC(S1)=C([C@H]2[C@H](CO)C2)N3C1=NC(COC4=CC=C(F)C=C4)=CC3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.