GNE-7915

Catalog No.: A13748

LRRK2 inhibitor

GNE-7915

GNE-7915 Chemical Structure

CAS NO. 1351761-44-8

GNE-7915 is a Blood-Brain Barrier (BBB) penetrable small molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2).

Availability: In stock

Package Price Qty
10 mg
$90.00
25 mg
$180.00
50 mg
$300.00
100 mg
$470.00
10mM * 1mL in DMSO
$100.00
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Biological Activity

GNE-7915 is a Blood-Brain Barrier (BBB) penetrable small molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2).
Targets
LRRK2 LRRK2
1 nM(Ki)9 nM
In vitro DMSO 22 mg/mL heating (49.61 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.55 mL 112.77 mL 225.53 mL
0.5 mM 4.51 mL 22.55 mL 45.11 mL
1 mM 2.26 mL 11.28 mL 22.55 mL
5 mM 0.45 mL 2.26 mL 4.51 mL

*The above data is based on the productmolecular weight 443.395. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13748
Actions Inhibitor
M. Wt 443.395
Formula C19H21F4N5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1351761-44-8
Synonyms GNE7915, GMS 7915
SMILES CCNC1=NC(=NC=C1C(F)(F)F)NC2=C(C=C(C(=C2)F)C(=O)N3CCOCC3)OC

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