Fig. 1 · Structure
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GNE-8324
GluN2A PAM
GNE-8324 is a selective positive allosteric modulator of the GluN2A subtype of NMDA receptors. This compound enhances NMDA receptor-mediated synaptic responses specifically in inhibitory neurons, while sparing excitatory neurons. GNE-8324 has potential applications in studying synaptic function and neuropharmacology, particularly in the context of cognitive disorders and neurodegenerative diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1698901-76-6 |
| Applications | GluN2A PAM |
| Formula | C18H18FN3OS |
| Molecular Weight | 343.42 |
| SMILES | O=C1C=C(CN(C2=CC=C(F)C=C2)CC)N=C3N1C(CCC4)=C4S3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.