Fig. 1 · Structure
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GNE-987 GSH linker-1
PROTAC-Linker Conjugate
GNE-987 GSH linker-1 is a PROTAC-linker conjugate designed for targeted protein degradation through the chimeric BET degrader GNE-987. Inactive in its original form, GNE-987 GSH linker-1 undergoes disulfide reduction and linker self-immolation to release the active degrader intracellularly. This compound is particularly useful in the study of acute myeloid leukemia, facilitating research into targeted therapeutics for this malignancy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2417370-39-7 |
| Applications | PROTAC-Linker Conjugate |
| Formula | C62H77F2N9O12S4 |
| Molecular Weight | 1306.58 |
| SMILES | O=C(CCCCCCCCCCNC(C1=C(CS(=O)(C)=O)C=C(C(N(C2=NC=C(F)C=C2F)C3)=C1)C4=CN(C)C(C5=C4C3=CN5)=O)=O)N[C@@H](C(C)(C)C)C(N6[C@H](C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)C[C@@H](OC(OCC(C)(C)SS(C)(=O)=O)=O)C6)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.