Fig. 1 · Structure
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GNE684
RIP1 Inhibitor
GNE684 is a selective inhibitor of receptor interacting protein 1 (RIP1), exhibiting mean Kiapp values of 21 nM, 189 nM, and 691 nM for human, mouse, and rat RIP1, respectively. This compound demonstrates significant biological activity in modulating necroptosis and inflammatory processes. GNE684 is a valuable tool for researchers studying cell death pathways and RIP1-related signaling in various disease contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2438637-64-8 |
| Applications | RIP1 Inhibitor |
| Formula | C23H24N6O3 |
| Molecular Weight | 432.48 |
| SMILES | COC1=NC=C(N(C)C([C@@H](NC(C2=NN([C@H](C3=CC=CC=C3)CC4)C4=N2)=O)CC5)=O)C5=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.