Fig. 1 · Structure
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GNF-1331
Porcupine Inhibitor
GNF-1331 is a selective and orally bioavailable inhibitor of Porcupine, demonstrating potent inhibition with an IC50 of 12 nM. This compound effectively blocks the secretion of Wnt ligands and downstream Wnt signaling activity, leading to substantial antitumor effects in the mouse MMTV-WNT1 xenograft tumor model. GNF-1331 serves as a valuable tool for research in cancer biology and Wnt signaling pathway modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 603101-22-0 |
| Applications | Porcupine Inhibitor |
| Formula | C20H20N6O2S2 |
| Molecular Weight | 440.54 |
| SMILES | O=C(CSC1=NN=C(N1CCC)C2=CC=NC=C2)NC3=NC4=CC=C(C=C4S3)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.